Regulation of Gonadotropin-Releasing Hormone (GnRH) Gene Expression by 5α-Dihydrotestosterone in GnRH-Secreting GT1–7 Hypothalamic Neurons1
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چکیده
منابع مشابه
Circadian gene expression regulates pulsatile gonadotropin-releasing hormone (GnRH) secretory patterns in the hypothalamic GnRH-secreting GT1-7 cell line.
Although it has long been established that episodic secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus is required for normal gonadotropin release, the molecular and cellular mechanisms underlying the synchronous release of GnRH are primarily unknown. We used the GT1-7 mouse hypothalamic cell line as a model for GnRH secretion, because these cells release GnRH in a pulsati...
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Galanin is colocalized with GnRH, and its expression in these neurons is enhanced at proestrus, a time of activation of GnRH neurons. We tested the hypothesis that the expression of both the GnRH and galanin mRNAs in GnRH neurons decrease during lactation in the rat, a reproductive state characterized by reduced gonadotropin secretion. For double label in situ hybridization, GnRH mRNA was detec...
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Gonadotropin-releasing hormone (GnRH) regulates reproduction. The human GnRH receptor lacks a cytoplasmic carboxy-terminal tail but has amino acid sequence motifs characteristic of rhodopsin-like, class A, G protein-coupled receptors (GPCRs). This review will consider how recent descriptions of X-ray crystallographic structures of GPCRs in inactive and active conformations may contribute to und...
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Departments of Anatomy Histology and Forensic Medicine and Clinical Physiopathology (AP,MM,GBV), Endocrinology (CC,PF,RS,CMR) and Andrology (MM,ML) Units, Genetic Unit (EP,FT), Departments of Internal Medicine (RGR), Preclinical and Clinical Pharmacology (PF), University of Florence, School of Medicine, Italy and Department of Experimental and Clinical Medicine (TB), University of Catanzaro, It...
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A non-mammalian lamprey-like gonadotropin-releasing hormone (lGnRH) has been detected in human hypothalami using a combination of immunocytochemistry, high performance liquid chromatography and radioimmunoassay. The hypothalamic distribution of immunopositive lGnRH neurons is similar to that observed for those containing the mammalian gonadotropin-releasing hormone (mGnRH), indicating a possibl...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 1998
ISSN: 0013-7227,1945-7170
DOI: 10.1210/endo.139.3.5846